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Deep Dive Into Cannabichromene And Its Unique Properties

Living in the 21st century, we can’t imagine our life without advertising. We see it everywhere, starting from the screen of our smartphones to the billboards outside our window. On the way to work, home, or just when walking in the evening with a dog, we see advertisement banners on which someone is telling us what to buy, how to save, and how to live overall. Statistics state that 57% of the world’s population (4.4 billion people) use the Internet, and if on the street, we can somehow turn away and enjoy looking at a bush of blooming jasmine nearby, then on the Internet one way or another we will have to watch a commercial every now and then. What does it all mean? Even while being indifferent to advertising, completely confident in our choice, sooner or later, we all think, maybe that guy from advertising was right? Add to this enthusiastic advice from a friend who bought the advertised product and did not regret it, and in any case, you will begin to doubt your choice. Advertising is the engine of progress — it should be taken as an axiom. It’s not bad, as, without ads, we wouldn’t know about lots of various things that are available right under our noses. However, there is also another side of this coin, as lots of similar products with the same benefits and price (or even cheaper and better) go unnoticed because of the lack of advertisement.

The problem of going unnoticed has touched the cannabis industry as well. The global hype focused on the THC and CBD has maximally concentrated the consumers’ attention on these two cannabinoids and therapeutic benefits they cause for our health, leaving all other compounds aside. Nevertheless, the worldwide buzz around cannabidiol and tetrahydrocannabinol has slightly subsided, giving way to other cannabinoids, names of which most of us haven’t even heard of before. The possibility of using cannabis and its compounds for medical purposes has triggered an avalanche of various studies, research, animal, and human trials. If at the beginning of the discovery of health benefits the cannabinoids can provide, THC and CBD were something like a world breakthrough in medicine, today more and more other cannabis compounds manifest similar properties that may also be used for a range of diseases and conditions. It doesn’t mean that research of CBD and THC properties has stopped or paused — it is still ongoing. The only difference is that at the same speed, other research and studies began to investigate the medicinal benefits of other cannabinoids, comparing them with the most studied compounds for today. It is the main reason why nowadays we often hear new names of cannabinoids with the health benefits that can also become a worthy alternative to modern drugs and even surpass them with higher efficiency and lack of side effects. CBC, or cannabichromene, is one of such “newcomers” in the cannabis world. It is yet not pampered with the world’s attention and popularity, so, for many of us, this name means absolutely nothing. In our review, we are going to dive deep into the therapeutic benefits of this cannabinoid and find out whether this compound deserves the place in one row with CBD and THC, or if it is doomed to always stay aside.

With such a vast amount of various information about CBD, its health benefits, and mechanism of action, it seems that nothing can surprise us. Thank God, we have the Internet, and after revealing the therapeutic properties of cannabinoids, we almost immediately could make sure that this is not one of the wonders of Shiva, but just a chain of fully explained chemical reactions and physiological interactions in our bodies.

Endocannabinoid system, CB1, and CB2 receptors, cannabinoids binding and interactions… Almost every cannabis article can maximally in detail explain the “magical” effects of cannabinoids on our body. As sceptics and cannabis experts, we think that nothing can surprise us and flip through this part of the articles to find something new. We dived deeper and are going to discover how does the well-known CBD oil impact cellular functions.

Mitochondria are found in large numbers within all cells, excluding red blood cells, and are responsible for generating up to 90% of the chemical energy that our cells need to survive. During the oxidative phosphorylation process, mitochondria act like a small yet powerful engine and turn nutrients into cell energy. Based on this, it seems evident that, if for some reason, mitochondria aren’t functioning correctly, it can have a highly negative impact not just in the cell, but throughout our body.

Moreover, mitochondria play a crucial role not only in energy production but in such processes as oxidative stress, homeostasis, healing, and destruction of cells as well. A range of different research has demonstrated that CBD oil and cannabinoids similar to it may be able to improve mitochondrial function. Cannabis specialists state that more research on CBD and mitochondria should further reveal the potential therapeutic effects of their interaction. It could shed more light on why CBD has been proven effective for managing an array of diseases and conditions. Let’s take a closer look at what research has been done to date.

Cannabidiol is thought to perform the autophagic and apoptotic responses through its impact on mitochondrial activity by way of the ECS or our endocannabinoid system. There are three different ways of how the endocannabinoid system works when it comes to cell stress:

Phytocannabinoids have a similar chemical structure to endocannabinoids that are naturally produced by our body, that’s why they are able to act on the human organism in a potent, but still familiar and relatively gentle way.

What is the CBD’s role in the process of reaching “ideal balance” or speaking in physiological terms, homeostasis? First of all, cannabidiol impacts particular receptors on the surface of mitochondria. One of the essential mitochondria receptors is called NCX or sodium-calcium exchanger. By binding with this receptor, CBD opens a channel, and ions can move freely on concentration gradient passing from high to low concentrations. Due to this process, cannabidiol regulates the flow of calcium through the NCX, thereby allowing reaching homeostasis state within the cell. Such a regulating effect of CBD oil on mitochondria and its management of the intracellular calcium levels could potentially have potent neuroprotective benefits.

To date, a wide range of products is claimed to be antidepressants, although CBD is considered as one of the most promising. After a range of research held and published in 1998, the US government filed a patent on the antioxidant properties of cannabinoids like CBD, suggesting that there may be a therapeutic use.

To date, with the total availability of any information you need, most of us are familiar with cannabinoids and their impact on our organism. With so much various information and reviews about THC and CBD, a significant part of other cannabinoids goes unnoticed despite their high therapeutic potential.

CBC or cannabichromene is a bright example of such “undervalued” compounds. Nevertheless, all in good time and not so long ago, this cannabinoid eventually has attracted attention from the world scientists that gave a push to numerous research and studies.

CBC was discovered over fifty years ago and, despite being one of the eight major cannabis cannabinoids, remained in the shade until recently. Today, cannabichromene is considered one of the most prominent in medical research cannabinoids as its benefits are extremely promising. Let’s take a closer look at the key cannabis compounds and evaluate the CBC’s origin and its interaction with other cannabinoids.

Cannabis is a unique plant that is able to produce a variety of different compounds. Some of the cannabis experts state that the precise number of these compounds is still unknown, although many sources say that there are more than a hundred unique cannabinoids produced by the cannabis plant. Most of these compounds are present at very low levels, while eight of them are known as “big eight” cannabinoids that are objects of interest for medicinal purposes. Neither CBD nor THC is directly associated with the cannabis plant. Instead of this, cannabis synthesizes several cannabinoid acids that must be decarboxylated or more straightforwardly — “activated.” The process of activation occurs by the heat or light and results in yielding the compounds that most consumers used to consume or read about, such as well known CBD and THC. Besides THCA and CBDA that are “precursors” to THC and CBD, respectively, there are a number of other related cannabinoid acids that can be produced by the cannabis plant. Among them are:

Each cannabinoid acid can be subsequently decarboxylated into a corresponding cannabinoid, such as THC, CBD, or THCV. For example, CBGA is a chemical precursor to THCA, CBDA, and CBCA, while CBGVA is a precursor to THCVA, CBDVA, and CBCVA. Among the most abundant cannabinoids in strains are THCA and CBDA. In comparison to them, other cannabinoid acids present at much lower levels. Cannabinoid acids that are considered to be major, include:

Among all of these acids, CBGA is known as the starting compound that enzymes in the cannabis plant always use to make the other three.

In contrast to THC, none of the cannabinoid acids can cause intoxicating effects. However, these compounds have a wide range of other interesting properties. For example, many cannabinoid acids have insecticidal and antibiotic properties. Some cannabis experts assume that the availability of such properties in quite a large number of cannabis compounds may be linked to the reason cannabis produces these compounds in the first place: to defend itself. Working like a foundation without which any building would stand, cannabinoid acids “give birth” to plant cannabinoids that we are more or less familiar with. When being exposed by the heat or light, cannabinoid acids lose “A” letter in their names, meaning they turn from acidic to neutral compounds, and transform into plant cannabinoids.

The transformation of THCA to THC is one of the decarboxylation examples. Similarly to this, all other cannabinoid acids can also be decarboxylated into their cannabinoid counterparts. Thus, due to this chemical process, each of the cannabinoid acids yields a corresponding cannabinoid compound:

Most of these cannabinoids will not get you “high.” According to all the studies held for the moment, THC is the only compound that is known for sure to have clear intoxicating effects on its own. There is also some evidence to suggest that THC is not alone in this property, and THCV may also have intoxicating effects. However, all the studies investigating this question agreed on the same — the presence and level of THCV psychoactivity depend on the dose. Nevertheless, THCV is usually not present in significant quantities in commercial cannabis products and strains like most other plant cannabinoids.

Even though most cannabinoids don’t have psychoactive properties, in many cases, their presence may influence the way how THC affects you. An example of such a “collaboration” is cannabidiol. It is well known that CBD can’t make you “high” on its own, although it may influence the way that THC interacts with the CB1 receptors in our endocannabinoid system, and, therefore, can influence how a cannabis-derived product will affect you. Similarly to CBD, THCV may also change the THC’s effects on our organism. THCV is also shown to diminish the ability of THC to activate CB1 receptors, like CBD. However, THCV may start to activate CB1 receptors, like THC, when taken at relatively high doses. The exact dosage of cannabinoids we consume can significantly change the way how the compound affects our organism.

When considering the interaction of cannabinoids and changes in their effects, we can’t pass by cannabichromene or CBC, which is the object of interest in our review. CBC has the same origin as both CBD and THC as they all stem from cannabigerolic acid (CBGA). As we already mentioned above, the cannabis plant produces CBGA, the precursor to three major cannabinoids: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). What determines in which of these acids CBGA will transform? The specific plant enzymes “direct” the breakdown product into one of the three lines. For CBC, it converts CBGA into cannabichromene carboxylic acid (CBCA), and then finally to CBC after exposure to heat or ultraviolet light.

Now it’s time for reviewing the essential moment regarding each cannabinoid — its therapeutic potential. Health benefits are the decisive factor for all the cannabis compounds. They are the main “trump card” of each cannabinoid and the green light for its research and further potential use. Scientists have high hopes for cannabichromene as the purported benefits of CBC seem to have far-reaching implications. Let’s take a look at the most studied CBC health benefits.

The therapeutic promise of cannabichromene is quite impressive, and its health benefits make it definitely worth getting out of the shadows and occupy its deserved place near other, more well-known cannabinoids. As with all other cannabis compounds that are discovered today, CBC also needs more research, laboratory and clinical studies, and trials. Its ability to provide therapeutic effects both independently and by working together with other cannabinoids for an entourage effect needs to be confirmed not only theoretically but also practically. Nowadays, patients are limited in the cannabis products available to them, although as new studies emerge, new medicines with a diversity of cannabinoids will soon become a worthy alternative to habitual drugs.

To fully enjoy the full spectrum of cannabichromene benefits, it is highly recommended to choose the most suitable way of cannabinoid taking, stop your choice on a high-quality CBD-oil, and pick the cannabis strains according to your local laws.

Today, there are a couple of different ways to enjoy CBC, although, as a rule, your options will differ depending on the current laws in your country. Many people stop their choice of cannabis strains highest in CBC. However, you should take into account that such strains usually contain THC, which means smoking cannabis to get CBC benefits is not an option that is available for everyone. Nevertheless, if you live in a cannabis-friendly state and are interested in trying some strains rich in cannabichromene, here are a few strains you may enjoy:

We have reviewed the three most popular CBC heavy sativas, although, besides them, there are also CBC heavy indicas that can provide you with their maximal effectiveness as well. Among CBC heavy indicas are:

One of the important considerations regarding cannabis strains highest in CBC is their legality. In case if you don’t live in a cannabis-friendly state or prefer other methods of CBC ingestion instead of smoking, there is another simple and user-friendly way to enjoy all the CBC benefits — to take full-spectrum CBD oil. As we know, CBD or famous cannabidiol is now federally legal worldwide. For cannabis consumers, it means that they can experience the benefits of cannabichromene by incorporating CBD oil into the daily routine.

Summing up everything we have collected about CBC, we can say for sure — this cannabinoid is worth to be noticed. Cannabichromene is worth attention not only from customers but also from the government and scientists. Global research should be expanded with the new studies investigating CBC properties and all its potential benefits that can be used as alternatives to a range of modern drugs in the future.

Cannabichromene shows a great promise for world medicine, although it still has some barriers on its way. The problem of legalization, adoption, and lack of studies still exists, and it will take time until all the health benefits of this cannabis compound are fully confirmed and approved by the government. Nevertheless, progress was ongoing, and CBC has started to catch attention from cannabis experts, scientists, and consumers. The growing popularity always entails a range of research and discoveries, so it is very likely that soon we will not only see the results of studies investigating existing CBC benefits but revealing new potential benefits of this compound on our health.

A great journey begins with a single step, and in the case of cannabichromene, this step was already made.

Anastasiia Myronenko

Anastasiia Myronenko is a Medical Physicist actively practicing in one of the leading cancer centers in Kyiv, Ukraine. She received her master’s degree in Medical Physics at Karazin Kharkiv National University and completed Biological Physics internship at GSI Helmholtz Centre for Heavy Ion Research, Germany. Anastasiia Myronenko specializes in radiation therapy and is a fellow of Ukrainian Association of Medical Physicists.

This article includes the promotion of products and services sold on Alphagreen and affiliate links to other businesses.

Alphagreen and its materials are not intended to treat, diagnose, cure or prevent any disease. The information and products presented on this site are not intended for medical use nor do they make any medical claims. Always seek the advice of your physician or another qualified healthcare provider for any questions you have regarding a pre-existing medical condition, are pregnant and/or are breastfeeding, and before undertaking any diet, exercise or another health-related program.

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